Thiamine chloride hydrochloride
Thiamine hydrochloride
CAS: 67-03-8
Molecular Formula: C12H17N4OS.ClH.Cl
Thiamine chloride hydrochloride - Names and Identifiers
Thiamine chloride hydrochloride - Physico-chemical Properties
| Molecular Formula | C12H17N4OS.ClH.Cl |
| Molar Mass | 337.27 |
| Density | 1.3766 (rough estimate) |
| Melting Point | 250°C (dec.)(lit.) |
| Flash Point | 9°C |
| JECFA Number | 1030 |
| Water Solubility | 1 g/mL |
| Solubility | H2O: 0.1g/mL at20°C, clear, colorless |
| Appearance | Crystalline Powder |
| Color | White to almost white |
| Merck | 14,9295 |
| BRN | 3851771 |
| pKa | pKa 4.8 (Uncertain);9.0 (Uncertain) |
| PH | 2.7-3.3 |
| Storage Condition | room temp |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents. |
| Sensitive | Light Sensitive & Hygroscopic |
| Refractive Index | 1.6000 (estimate) |
| Physical and Chemical Properties | Melting point 250°C (dec.)(lit.) FEMA 3322 Storage Conditions 2-8°C solubility H2O: 0.1g/mL at 20°C, clear, colorless water solubility 1 g/mL sensitivity Light Sensitive & hygropic Merck 14,9295 BRN 3851771 |
| Use | For vitamin B1 deficiency |
Thiamine chloride hydrochloride - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| RTECS | XI7350000 |
| FLUKA BRAND F CODES | 3-8-10 |
| TSCA | Yes |
| HS Code | 29362200 |
| Toxicity | LD50 in mice (mg/kg): 89.2 i.v.; 8224 orally (Winter) |
Thiamine chloride hydrochloride - Nature
Open Data Verified Data
White fine crystal or crystalline powder. Pure odorless, usually due to the trace decomposition of sulfur-containing products with rice bran odor, bitter taste. 248 degrees C decomposition. Easily soluble in water, lg is soluble in 1 mL water, 18mL glycerol, lOOmL 95% ethanol, 315 mL anhydrous ethanol, slightly soluble in ethanol, insoluble in ether benzene, easily soluble in methanol, soluble in propylene glycol, practically insoluble in ether, benzene, hexane and chloroform. 1% aqueous solution pH 3.13.0.1% aqueous solution pH 3.58. In the pH 2~4 of the aqueous solution is more stable, pH is more than 5.5 is unstable to heating, when ultraviolet light decomposition. In the dry state, it is stable in the air, and is exposed to the air to absorb water rapidly and decompose slowly.
Last Update：2024-01-02 23:10:35
Thiamine chloride hydrochloride - Preparation Method
Open Data Verified Data
It can be prepared from 4-amino-2-methyl-5-acetylaminomethylpyrimidine by hydrolysis, addition condensation, cyclization hydrolysis, oxidation, substitution and the like. Natural products exist in rice bran, germ, yeast and beans, etc., can be extracted from rice bran or yeast after hydrolysis.
Last Update：2022-01-01 09:27:28
Thiamine chloride hydrochloride - Use
Open Data Verified Data
used in medicine, biochemical research, fluorescence and phosphorescence analysis of phosphorus, fluorescence determination of Mercury.
Last Update：2022-01-01 09:27:29
Thiamine chloride hydrochloride - Safety
Open Data Verified Data
mouse LD50 (mg/kg):89.2 intravenously; 8224 orally.
Last Update：2022-01-01 09:27:29
Thiamine chloride hydrochloride - Reference Information
| FEMA | 3322 | THIAMINE HYDROCHLORIDE |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | thiamine hydrochloride (VB1), also known as thiamine, is the first water-soluble vitamin purified by people, the chemical name is 3-[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride hydrochloride, it has the function of maintaining normal glucose metabolism, and is commonly used in clinical prevention and treatment of beriberi caused by lack of VB1, and is also used for adjuvant treatment of neuritis, dyspepsia and other diseases. |
| usage limit | GB 14880-94(mg/kg): cereals and their products, beverages, milk and milk drinks, 3~5; Infant food 4~8. GB 2760-2002(mg/kg): prepared wine 1~2; Instant breakfast cereals 7.5~17.5; Jelly 1.0~7.0; Fruit juice (fruit flavor) beverage 2~3; cocoa powder and other flavor nutritional solid beverages 10~22 (the corresponding nutritional milk drinks according to the dilution factor to reduce the use of). Gum base candy 16~33; Milk containing solid beverage 0.089~0.187; Soybean milk powder, soybean powder, 6~15; Soybean milk, soybean milk, 1~3. moderate limits (FDA,§ 184.1875,2000). FEMA(mg,Ikg): beverages, baked goods, meat, meat sausage, broth, milk and dairy products, spices, cereal products, all 50. |
| physiological function | thiamine hydrochloride is a form of vitamin B1, use: nutritional supplement. Vitamin B1 is involved in the intermediary metabolism of carbohydrates in the body. The deficiency of vitamin B1 in the body, the activity of supplementary carboxylase decreases, and the sugar metabolism is blocked, which affects the whole body metabolism process. The acetone was hindered in decarboxylation and could not enter the tricarboxylic acid cycle. It did not continue to oxidize and accumulated in the tissue. At this time, the nerve tissue is insufficient, so the corresponding neuromuscular symptoms can occur, such as multiple neuritis, muscle atrophy and edema, and can affect the function of myocardium and brain tissue in severe cases. Vitamin B1 deficiency can also cause indigestion, loss of appetite and constipation. |
| deficiency | vitamin B1 plays an important role in maintaining normal nerve conduction and normal activities of the heart and digestive system. Lack of susceptibility to beriberi or multiple neuritis and other symptoms. China's provisions can be used for infant food, the use of 4~8 mg/kg; In cereals and their products in the use of 3.0~5.0mg/kg; In the drink, the amount used in the milk drink is 1-2 mg/kg. This product can be strengthened with thiamine nitrate, and the specific dosage must be converted. This product plays an important role in sugar metabolism. The energy of nerve tissue is mainly used to supply sugar metabolism. Once the lack of vitamin B1 is produced, the energy supply is impaired, and the accumulation of lactic acid and pyruvate leads to polyneuritis, which shows abnormal sensation, weakness of limbs, neuromuscular soreness and atrophy, at the same time, myocardial metabolism disorder, heart palpitations, chest tightness, cardiac hypertrophy, liver blood stasis and peripheral edema and other symptoms of cardiac insufficiency. Retinin B1 mild lack tabulated inappetence and weight loss and weakness, etc. For vitamin B1 deficiency, high fever, hyperthyroidism, a large number of glucose infusion, systemic infection, diabetes and polyneuritis. |
| solubility | 1 g/mL water, 1g/18 mL glycerol, 1g/100 mL ethanol, 1g/315 of absolute ethanol, soluble in propylene glycol, practically insoluble in ether, benzene, hexane and chloroform. |
| content analysis | GB 14751-93 method arbitration method (GB 14751 93) accurate sample 0.05g, after dissolving 50ml of water, 2ml of hydrochloric acid was added and boiled, 4ml of 10% silicotungstic acid solution was added dropwise immediately, the solution was boiled for 2 hours, and filtered through a glass Crucible dried to constant weight at 80 °c. The precipitate was first washed in portions with boiling (1-20) hydrochloric acid (20 ml). It was washed once with 10ml of water and finally twice with 5ml of acetone each time, and dried to constant weight at 80 °c. Weighing. Vitamin B1(%)=(m1 × 0.1939 × 100)/m2 ×(1-X2) wherein m1-weight of precipitate after drying, g;m2-sample volume, g; x2 a sample loss on drying, Y; 0.1939 -- thiamine hydrochloride silicotungstate salt converted into thiamine hydrochloride factor. Non-aqueous titration method (GB 14751-93) accurately weigh about 160mg of sample, add glacial acetic acid 20ml, dissolve slightly hot, cool to room temperature, add 5% mercury acetate solution 5ml, 2 drops of quinaldine red-methylene blue mixed indicator (quinaldine Red 0.3g, methylene blue 0.1g, dissolved in 0.1 methanol), Titrate to sky blue with mol/L perchloric acid standard solution, strong shaking, half a minute does not fade as the end point, while the blank test. Vitamin B1(%)=(V-V0)×c× 0.1686 × 100/m3 ×(1-x2) the difference of perchloric acid standard solution consumed between the medium (V-V0)-Sample and blank, m1;c-perchloric acid standard solution concentration, mol/L;m3-sample volume, g;X2-Loss on drying,%;0.1686-per mL of 1.00mol/L perchloric acid standard solution is equivalent to the amount of vitamin B, g. FCC process special solution and solvent potassium chloride solution dissolve 250g potassium chloride (KCl) in enough water to make 1000ml. The acidic potassium chloride solution was added with 8.5ml of hydrochloric acid in 1000mL of potassium chloride solution. 1% potassium ferricyanide solution dissolve 1G potassium ferricyanide K3Fe(CN)6 in enough water to make it 100ml, and prepare it on the day of use. Oxidizing agent 4.0 mL l% potassium ferricyanide solution was mixed with enough 3.5mol/L sodium hydroxide to make mL. This solution was used within 4H. 10mg of quinine sulfate [(C20H24N2O2)2? H2SO4? 2H2O] Dissolved in enough 0.1mo/L sulfuric acid to make 1000ml. Store this solution in the refrigerator in the dark. Quinine sulfate standard solution one volume of quinine sulfate mother solution was diluted with 39 volumes of 0.1mol/L sulfuric acid. The intensity of the fluorescence emitted by this solution is approximately the same as that obtained with 1 μg of thiamine hydrochloride, and the fluorometer should be calibrated frequently because the sensitivity changes at each reading within the detection range. The solution was prepared on the day of use. Preparation of thiamine hydrochloride standard mother liquor 25mg of reference standard thiamine hydrochloride of pharmacopoeia grade, pre-dried at 105 ℃ for 2H, was accurately weighed and transferred into a 1000ml volumetric flask for careful observation, avoid absorbing moisture when weighing dry standards. The weighed standard was dissolved in about 20% of dilute ethanol solution (4.0), the pH was adjusted to with dilute hydrochloric acid solution (TS-117), and acidified dilute ethanol was added to the mark. Stored in a light-shielded container in a refrigerator. This fresh mother liquor was prepared monthly. Preparation of the standard solution the absorption volume is exactly equivalent to 100 μg of the standard mother solution of the pharmacopoeia grade reference standard thiamine hydrochloride, transferred into a 100ml volumetric flask, and diluted to the mark with acidic potassium chloride solution. Take 10ml of this solution and dilute it accurately to 50.0ml with acidic potassium chloride solution. Each ml of the resulting standard solution contained 0.2 μg of the pharmacopoeia grade reference thiamine hydrochloride. Preparation of sample solution: weigh about 25mg of sample accurately, dissolve in enough acidic potassium chloride solution to 500ml, and mix well. 5ml of this solution was quantitatively and stepwise diluted with an acidic potassium chloride solution to a concentration of 0.2 μg of sample per ml. Four tubes (or other suitable containers) with a capacity of about 40ml or more are used for the measurement procedure. For three of these tubes, 3ml of oxidant was added rapidly (within 1 to 2s) with stirring, and 20ml of isobutanol was added within 30s, and the capped tubes were shaken by hand and mixed vigorously for 90s, or by air flow blowing through the mixture. A blank sample was prepared in the remaining standard test tube using an equal volume of 3.5mol/L sodium hydroxide instead of the oxidizing agent and operated in the same manner. 5ml of each sample solution was taken from four or more identical test tubes. The tubes were treated in the same manner as the tubes containing the standard solution. Add 2ml of absolute ethanol to each of the above eight test tubes, shake for a few seconds, separate the phases, and gently pour about 10ml of the transparent supernatant isobutanol solution into a standard cuvette, fluorescence is measured in a suitable fluorophotometer. A population filter having a maximum absorption transmission region at about 365nm and an exit filter having a maximum absorption transmission region at about 435nm were used. Calculate the thiamine hydrochloride (C12Hl 7C1N4OS? mg number of HCI): mg number = 25(A-b)/(s-d) where A- average reading of fluorometer of sample solution treated with oxidant; B- fluorescence photometer reading of blank sample solution; s-average fluorescence photometry reading of standard solution treated with oxidant; d-fluorescence photometer reading of blank standard solution. |
| toxicity | LD50>7700-15000mg/kg (mouse, oral). GRAS(FDA,§ 182.5875,2000). |
| Use | vitamin B1 plays an important role in maintaining normal nerve conduction and normal activities of the heart and digestive system. Lack of susceptibility to beriberi or multiple neuritis and other symptoms. China's provisions can be used for infant food, the use of 4~8 mg/kg; In cereals and their products in the use of 3.0~5.0mg/kg; In the drink, the amount used in the milk drink is 1-2 mg/kg. This product can be strengthened with thiamine nitrate, and the specific dosage must be converted. biochemical research, fluorescence and phosphorescence analysis of phosphorus, clinical drugs belong to vitamin B family, for the Prevention of beriberi, multiple neuritis, central nervous system injury and other diseases. |
| production method | acetamidine and α-dimethoxymethyl-β-methoxypropionitrile in the presence of sodium alkoxide, the pyrimidine derivative is produced by condensation and hydrolysis, and the latter reacts with carbon dioxide and ammonia, and then condenses with acetic acid-gamma-chloro-Delta-acetyl propyl ester, acid hydrolysis and cyclization to obtain thiothiamine hydrochloride, after neutralization with ammonia, oxidation with hydrogen peroxide, ammonium nitrate is converted into thiamine nitrate, and finally hydrochloric acid is added. vitamin B1 is naturally found in rice bran, Bran, lean meat, peanut and other foods. Pure products are usually prepared by chemical synthesis. An excess of acetamidine hydrochloride is condensed with α-dimethoxy-β-methoxypropionitrile in basic (methanol and sodium methoxide) media to Form 3, 6-dimethyl-1, 2-dihydro-2, 4,5, 7-tetrahydronaphthalene was hydrolyzed at 98~100 ℃ and then ring-opened under alkaline condition to produce 2-methyl -4-amino -5-aminomethyl pyrimidine; then with carbon disulfide and ammonia, and then with acetic acid-gamma-chloro-gamma-acetyl propyl ester condensation, and then in hydrochloric acid, 75~78 deg C hydrolysis and ring synthesis of thiothiamine hydrochloride, finally, thiamine hydrochloride was obtained by neutralization with ammonia, oxidation with hydrogen peroxide and acidification with hydrochloric acid. Natural products exist in rice bran, germ, yeast and beans, and can be extracted from rice bran or yeast after hydrolysis. There are many synthetic methods. It can be prepared from 4-amino-2-methyl-5-acetylaminomethylpyrimidine by hydrolysis, addition condensation, cyclization hydrolysis, oxidation, substitution and the like. |
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsMultiple SpecificationsSpot supply
Product Name: vitamin B1 Visit Supplier Webpage Request for quotationCAS: 67-03-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Thiamine hydrochloride Request for quotationCAS: 67-03-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Thiamine hydrochloride Request for quotation
CAS: 67-03-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 67-03-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Thiamine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 67-03-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Thiamine hydrochloride Request for quotation
CAS: 67-03-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 67-03-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Thiamine hydrochloride (Vitamine B1 ) Request for quotation
CAS: 67-03-8
Tel: 051086995770
Email: sales@premiumingredient.com
Mobile: 18652482205
QQ: 609149175
Send QQ message
CAS: 67-03-8
Tel: 051086995770
Email: sales@premiumingredient.com
Mobile: 18652482205
QQ: 609149175
Featured ProductsMultiple SpecificationsSpot supply
Product Name: vitamin B1 Visit Supplier Webpage Request for quotationCAS: 67-03-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Thiamine hydrochloride Request for quotationCAS: 67-03-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: Thiamine hydrochloride Request for quotation
CAS: 67-03-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 67-03-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Spot supply
Product Name: Thiamine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 67-03-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Thiamine hydrochloride Request for quotation
CAS: 67-03-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 67-03-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Thiamine hydrochloride (Vitamine B1 ) Request for quotation
CAS: 67-03-8
Tel: 051086995770
Email: sales@premiumingredient.com
Mobile: 18652482205
QQ: 609149175Send QQ message
CAS: 67-03-8
Tel: 051086995770
Email: sales@premiumingredient.com
Mobile: 18652482205
QQ: 609149175
View History